Generating high-quality genome drafts from uncultured microbiome samples with a single shotgun experiment
This webinar will feature a presentation on a recently published method for de novo assembly of microbial genome drafts using short read sequencing. The method uses Chromium Linked-Read sequencing and a novel computational analysis pipeline, Athena, to construct high-quality microbial genome drafts of metagenomic communities sampled directly from their environments. In uncultured samples from human stool, Athena produced individual genome drafts with high contiguity (>200-kb N50, fewer than ten contigs), even for bacteria with relatively low raw short-read sequence coverage. Compared with results from existing short-read and synthetic long-read metagenomic sequencing techniques, the Athena assemblies are the most contiguous reported to date.

Dr. Ami Bhatt, MD, PhD
Assistant Professor of Medicine and Genetics
Stanford University

Feb 13, 2019 09:00 AM in Pacific Time (US and Canada)

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